Ethanol → n-Allyl-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide

Participants

Reaction Steps

A solution of N-allyl-2-acetyl-6-chloro-3-nitrobenzenesulfonamide (30 mg, 009 mmol), 0.mL of chlorotrimethylsilane and 2 drops of fuming sulfuric acid in ethanol was heated to reflux for 20 hours. The solvent was evaporated. The residue was diluted with ethyl acetate and washed with water. The organic layer was then dried (Na,SO4) and concentrated to give the desired product (26 mg, 100%). 1H NMR (MeOD-d4): δ 8.01(d, 1H), 7.20 (d, 1H), 5.70 (m, 1H), 5.16 (m, 1H), 5.05 (m, 1H), 3.62 (m, 2H).

Provenance & Evidence