1,2-Dichloro-3-isocyanatobenzene → N-[3-(N''-allylaminosulfonyl)4-chloro-2-hydroxyphenyl]-N'-(2,3-dichlorophenyl) urea

Participants

Reaction Steps

A solution of crude N-allyl-3-amino-6-chloro-2-hydroxybenzenesulfonamide (20 mg) and 2,3-dichlorophenylisocyanate (12 μL, 0.09 mmol) in 1 mL of N,N-dimethylformamide was stirred at room temperature for 20 hours. The mixture was diluted with ethyl acetate and washed with water to give the crude material. Purification by column chromatography on silica gel, eluting with ethyl acetate/hexane (30/70, v/v), gave the desired product (10 mg, 29% for two steps). EI-MS (m/z) 450.2, 452.2, 454.1 (M−).

Provenance & Evidence