HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-[(2,6-Dichloro-3-nitrophenyl)sulfonyl]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride | HCID 23447772 | — |
| Product | 4-[(2,6-Dichloro-3-nitrophenyl)sulfonyl]morpholine | HCID 17927814 | 73.3% |
Reaction Steps
Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (500 mg, 1.72 mmol), morpholine (150 mg, 1.72 mmol) and triethylamine(479 μL, 3.44 mmol) were reacted to form the desired product (430 mg, 73%). LC-MS (m/z) 341.0 (M−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500863B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-e50fa3166a7a440c9de1039f83250c9a |
| Source note | uspto-grants-2002_12 |