HCID 18373436, compound → HCID 18373571, compound

HRID 2301530Notes

Reaction equation

HRID 2301530 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][S:13]([C:16]1[C:21]([Cl:22])=[CH:20][CH:19]=[C:18]([N+:23]([O-])=O)[C:17]=1[OH:26])(=[O:15])=[O:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd]>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][S:13]([C:16]1[C:21]([Cl:22])=[CH:20][CH:19]=[C:18]([NH2:23])[C:17]=1[OH:26])(=[O:15])=[O:14])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 18373436HCID 18373436, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373571HCID 18373571, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

N-[3-(tert-butoxycarbonylamino)propyl]-6-chloro-2-hydroxy-3-nitrobenzene-sulfonamide (250 mg, 0.61 mmol) was reduced with hydrogen and 10% Pd/C (100 mg) to form the desired product (220 mg, 95%). 1H NMR (MeOD-d4): δ 6.82 (m, 2H), 3.06 (t, 2H), 2.92 (t, 2H), 1.60 (m, 2H), 1.41 (s, 9H).

Sources & evidence

ORD record
ord-a4f50cb93e2e4f6c9862236e75ffdd50
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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