HCID 18373540, compound → HCID 18373502, compound

HRID 2301540Notes

Reaction equation

HRID 2301540 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:22]([Cl:23])=[CH:21][CH:20]=[C:19]([N+:24]([O-])=O)[C:18]=2[OH:27])(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]([OH:27])=[C:19]([CH:20]=[CH:21][C:22]=2[Cl:23])[NH2:24])(=[O:15])=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 18373540HCID 18373540, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373502HCID 18373502, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, 1-[4-(tert-butoxycarbonyl)piperazin-1-yl]sulfonyl-6-chloro-2-hydroxy-3-nitrobenzene (256 mg, 0.61 mmol) was reduced with hydrogen and 10% Pd/C (120 mg) to form the desired product (220 mg, 93%). 1H NMR (MeOD-d4): δ 6.84 (m, 2H), 3.45 (m, 4H), 3.27 (m, 4H), 1.43 (s, 9H).

Sources & evidence

ORD record
ord-847dc8822bb841e1ae2776dbb81ba57c
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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