HCID 18373529, compound → HCID 18373448, compound

HRID 2301547Notes

Reaction equation

HRID 2301547 reaction equation
[CH3:1][S:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-])=O)[C:11]=1[OH:20])(=[O:9])=[O:8].[H][H]>[Pd]>[CH3:1][S:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([NH2:17])[C:11]=1[OH:20])(=[O:9])=[O:8]

Participants

4

Reactant 2

HCID 18373529HCID 18373529, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373448HCID 18373448, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

N-(3- methylthiopropyl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (300 mg, 0.88 mmol) was reduced with hydrogen and 10% Pd/C (150 mg) to form the desired product (250 mg, 91%). 1H NMR (MeOD-d4): δ 6.84 (d, 1H), 6.77 (d, 1H), 2.93 (t, 2H), 2.40 (t, 2H), 1.89 (s, 3H), 1.63 (m, 2H).

Sources & evidence

ORD record
ord-c190e9ddc08948d481ad123864600727
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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