Urea → HCID 11663321, compound

Participants

Reaction Steps

Following the general procedure for urea formation outlined in example 15, N-(3-methylthiopropyl)-3-amino-6-chloro-2-hydroxybenzenesulfonamide (250 mg, 0.80 mmol) and 2,3dichlorophenylisocyanate (1 82 mg, 0.97 mmol) were coupled to form the desired urea (278 mg, 70%). 1H NMR (MeOD-d4): δ 8.29 (d, 1H), 8.06 (d, 1H), 7.24 (m, 2H), 7.05 (d, 1H), 3.07 (t, 2H), 2.48 (t, 2H), 1.98 (s, 3H) 1.74 (m, 2H).

Provenance & Evidence