HCID 18373431, compound → HCID 18373428, compound

HRID 2301553Notes

Reaction equation

HRID 2301553 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:20][CH2:21][O:22][CH3:23])[S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-])=O)[C:10]=1[OH:19])(=[O:8])=[O:7].[H][H]>[Pd]>[CH3:23][O:22][CH2:21][CH2:20][N:5]([CH2:4][CH2:3][O:2][CH3:1])[S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([NH2:16])[C:10]=1[OH:19])(=[O:7])=[O:8]

Participants

4

Reactant 2

HCID 18373431HCID 18373431, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373428HCID 18373428, compoundYield 87.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, N,N-di-(2-methoxyethyl)-6chloro-2-hydroxy-3-nitrobenzenesulfonamide (100 mg, 0.27mmol) was reduced with hydrogen and 10% Pd/C (50 mg) to form the desired product (80 mg, 87%). 1H NMR (MeOD-d4): δ 6.85 (m, 2H), 3.58 (t, 4H), 3.47 (t, 4H), 3.21 (s, 6H).

Sources & evidence

ORD record
ord-d8509ea06c6b4acda57d7ff46c2ed091
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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