Bromhydrol → HCID 11555271, compound

Participants

Reaction Steps

A solution of N-(2-bromophenyl)-N′[4-chloro-3-[N″,N″-di-(2-methoxyethyl)-aminosulfonyl]-2-hydroxyphenyl] urea (9.9 mg, 0.018 mmol) and aluminum bromide (4.2 mg, 0.018 mmol) in 2 mL of ethanethio was stirred for 16 hours at room temperature. The mixture was concentrated. The residue was diluted with ethyl acetate, then washed with 1 N aq. HCl, the organic layer was dried over MgSO4 and concentrated. Recrystallization from acetone and methanol gave the desired product (4 mg, 44%). 1H NMR (MeOD-d4): δ 8.30 (d, 1H), 7.92 (d 1H), 7.59 (d, 1H), 7.33 (t, 1H), 7.07 (d, 1H), 7.01 (t, 1H), 3.68 (t, 414), 3.51 (m, 4H).

Provenance & Evidence