HCID 54535072, compound → HCID 53691666, compound

HRID 2301561Notes

Reaction equation

HRID 2301561 reaction equation
[N:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-])=O)[C:14]=2[OH:23])(=[O:12])=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>[Pd]>[N:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([NH2:20])[C:14]=2[OH:23])(=[O:12])=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 54535072HCID 54535072, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53691666HCID 53691666, compoundYield 108.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, crude N-[2-(morpholinyl)ethyl]-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (300 mg) was reduced with hydrogen and 10% Pd/C (80 mg) to form the crude product (300 mg) which was carried onto the urea step without purification. EI-MS (m/z) 338.93, 340.98 (M+).

Sources & evidence

ORD record
ord-9bc9c678314546928542ad18ef4cef17
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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