Water → HCID 18373470, compound

Participants

Reaction Steps

Following the general hydrolysis procedure outlined in example 15, N-[5-(tert-butoxycarbonylamino)-5-methoxycarbonylpentyl]-2,6-dichloro-3-nitrobenzenesulfonamide (1.2 g, 2.33 mmol), 60% NaH (379 mg, 9.32mmol) and water (84 μL, 4.66 mmol) were reacted to form the desired product (850 mg, 76%). 1H NMR (MeOD-d4): δ 8.05 (d, 1H), 7.22 (d, 1H), 4.00 (m, 1H), 3.01 (t, 2H), 1.72 (m, 2H), 1.50-1.65 (m, 4H), 1.44 (s, 9H).

Provenance & Evidence