HCID 86588374, compound → HCID 86588375, compound

HRID 2301613Notes

Reaction equation

HRID 2301613 reaction equation
[N:1]1([C:6]2[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8]([OH:17])[C:7]=2[N+:18]([O-])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>[Pd]>[N:1]1([C:6]2[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8]([OH:17])[C:7]=2[NH2:18])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 86588374HCID 86588374, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86588375HCID 86588375, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, (N-pyrrolidinyl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (0.73 g, 2.4 mmol) was reduced with hydrogen and 10% Pd/C (0.73 g) to form the desired product (0.69 g, crude). MS m/z (M+H) 276.9, 278.89, 279.88.

Sources & evidence

ORD record
ord-288489db229340acbfc03d3e3d01fabc
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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