HCID 18373524, compound → HCID 18373508, compound

HRID 2301616Notes

Reaction equation

HRID 2301616 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-])=O)[C:12]=2[OH:21])(=[O:10])=[O:9])=[CH:3][CH:2]=1.[H][H]>[Pd]>[N:1]1[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([NH2:18])[C:12]=2[OH:21])(=[O:10])=[O:9])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 18373524HCID 18373524, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373508HCID 18373508, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, N-(4-pyridinyl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (22.0 mg, 0.066 mmol) was reduced with hydrogen and Pd/C (10.3 mg) to form the desired product (18.0 mg, 90%). EI-MS m/z 298(M-H)−.

Sources & evidence

ORD record
ord-48a7a4158dae49afbdc4a625f096761e
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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