HCID 54510442, compound → HCID 54564588, compound

HRID 2301619Notes

Reaction equation

HRID 2301619 reaction equation
[CH2:1]([NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-])=O)[C:12]=1[OH:21])(=[O:10])=[O:9])[C@@H:2]1[O:6][CH2:5][CH2:4][CH2:3]1.[H][H]>[Pd]>[CH2:1]([NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([NH2:18])[C:12]=1[OH:21])(=[O:9])=[O:10])[C@@H:2]1[O:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 54510442HCID 54510442, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54564588HCID 54564588, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, N-((2R)-tetrahydrofurfuryl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (660 mg, 1.96 mmol) was reduced with hydrogen and Pd/C (303 mg) to form the desired product (563 mg, 94%). EI-MS mn/z 305(M-H)−.

Sources & evidence

ORD record
ord-f5a38ad607a94362a8bd810518f964c2
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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