HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-((2S)-Tetrahydrofurfuryl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 69824390 | HCID 69824390 | — |
| Product | N-((2S)-Tetrahydrofurfuryl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide | HCID 69824924 | 26.4% |
Reaction Steps
Following the general hydrolysis procedure outlined in example 15, N-((2S)-tetrahydrofurfuryl)-2,6-dichloro-3-nitrobenzenesulfonamide (1.12 g, 3.15 mmol), 80% NaH (284 mg, 9.47 mmol) and water (0.057 mL, 3.16 mmol) were reacted to form the desired product (280 mg, 26%). EI-MS m/z 335(M-H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500863B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c9513321b9844e808c0879998894269c |
| Source note | uspto-grants-2002_12 |