HCID 69824924, compound → HCID 69824535, compound

HRID 2301622Notes

Reaction equation

HRID 2301622 reaction equation
[CH2:1]([NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-])=O)[C:12]=1[OH:21])(=[O:10])=[O:9])[C@H:2]1[O:6][CH2:5][CH2:4][CH2:3]1.[H][H]>[Pd]>[CH2:1]([NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([NH2:18])[C:12]=1[OH:21])(=[O:9])=[O:10])[C@H:2]1[O:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 69824924HCID 69824924, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69824535HCID 69824535, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, N-((2S)-tetrahydrofurfuryl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (270 mg, 0.80 mmol) was reduced with hydrogen and Pd/C (140 mg) to form the desired product (226 mg, 94%). EI-MS m/z 305(M-H)−.

Sources & evidence

ORD record
ord-95e27785b5284ec5b2f7d2413c12aa32
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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