HCID 86588376, compound → HCID 86588377, compound

HRID 2301633Notes

Reaction equation

HRID 2301633 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][N:2]1[C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8]([OH:17])[C:7]=1[N+:18]([O-])=O.[H][H]>[Pd]>[O:1]1[CH2:5][CH2:4][CH2:3][N:2]1[C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:14])=[O:15])=[C:8]([OH:17])[C:7]=1[NH2:18]

Participants

4

Reactant 2

HCID 86588376HCID 86588376, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86588377HCID 86588377, compoundYield 128.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, (N-tetrahydroisoxazyl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (0.76 g, 2.35 mmol) was reduced with hydrogen and 10% Pd/C (0.76) to form the desired product (0.89 g, crude). LC-MS m/z 293(M+).

Sources & evidence

ORD record
ord-eca0a8f05f86414eacc939ac4415eb9a
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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