HCID 18373494, compound → HCID 18373561, compound

HRID 2301636Notes

Reaction equation

HRID 2301636 reaction equation
[CH:1]([O:4][CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-])=O)[C:12]=1[OH:21])(=[O:10])=[O:9])([CH3:3])[CH3:2].[H][H]>[Pd]>[CH:1]([O:4][CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([NH2:18])[C:12]=1[OH:21])(=[O:10])=[O:9])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 18373494HCID 18373494, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373561HCID 18373561, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, crude N-(2-isopropoxyethyl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (1.17 g) was reduced with hydrogen and Pd/C (350 mg). The crude product (1.086 g) was carried on to the next step without purification. 1H NMR (MeOD-d4): δ 6.92 (d, 1H), 6.85 (d, 1H), 3.45 (m, 1H), 3.39 (t, 2H), 3.10 (t, 2H), 1.05 (d, 6H).

Workup

  1. customThe crude product (1.086 g) was carried on to the next step without purification

Sources & evidence

ORD record
ord-fc5cb90e15aa42b88b145eb0d4bf67ff
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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