HCID 18373452, compound → HCID 18373443, compound

HRID 2301639Notes

Reaction equation

HRID 2301639 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-])=O)[C:11]=1[OH:20])(=[O:9])=[O:8])[CH3:2].[H][H]>[Pd]>[CH2:1]([O:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([NH2:17])[C:11]=1[OH:20])(=[O:9])=[O:8])[CH3:2]

Participants

4

Reactant 2

HCID 18373452HCID 18373452, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373443HCID 18373443, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, crude N-(2-ethoxyethyl)-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (0.98 g) was reduced with hydrogen and Pd/C (250 mg). The crude product (1.01 g) was carried onto the next step without purification. 1H NMR (MeOD-d4): δ 6.88 (m, 2H), 3.40 (t, 2H), 3.36 (m, 2H), 3.13 (t, 2H), 1.08 (t, 3H).

Workup

  1. customThe crude product (1.01 g) was carried onto the next step without purification

Sources & evidence

ORD record
ord-9166d3d830084174a4913f911188fc90
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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