HCID 18373533, compound → HCID 18373536, compound

HRID 2301642Notes

Reaction equation

HRID 2301642 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][NH:10][S:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[C:16]([N+:21]([O-])=O)[C:15]=2[OH:24])(=[O:13])=[O:12])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>[Pd]>[N:1]1([CH2:7][CH2:8][CH2:9][NH:10][S:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[C:16]([NH2:21])[C:15]=2[OH:24])(=[O:13])=[O:12])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 18373533HCID 18373533, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373536HCID 18373536, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, crude N-[3-(4-morpholinyl)propyl]-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (1.01 g) was reduced with hydrogen and 10% Pd/C (250 mg). The crude product (890 mg) was carried onto the next step without purification. 1H NMR (MeOD-d4): δ 6.86 (m, 2H), 3.87 (m, 4H), 3.15 (m, 6H), 2.98 (t, 2H), 1.92 (m, 2H).

Workup

  1. customThe crude product (890 mg) was carried onto the next step without purification

Sources & evidence

ORD record
ord-3dd33e16e66a44c8871b12b63d141408
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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