HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-(6-chloro-7H-purin-2-yl)acetamide | HCID 6098997 | — |
| Reactant | 2,3,5-tri-O-acetyl-beta-D-ribofuranosylpurine | HCID 69884339 | — |
| Catalyst | Mercurous Chloride | HCID 24182 | — |
| Product | 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine | HCID 14284102 | — |
Reaction Steps
The chloromercury derivative of 2-acetamido-6-chloropurine is condensed with 2,3,5-tri-O-acetyl-β-D-ribofuranosylpurine utilizing the method of Lee et. al. (1971), J. Med. Chem., 14:819. The condensation product was treated with ammonia to yield 2-amino-6-chloro-9-(β-D-xylofuranosyl)purine. Further treatment with sodium hydroxyethylmercaptide gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500945B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-68da2c14632043628907c73fdf46fa0d |
| Source note | uspto-grants-2002_12 |