9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-beta-D-threo-pentofuranosyl]-9H-purine-6-amine → Lodenosine

Participants

Reaction Steps

35.3 mg (0.0710 mmols) of 9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine-6-amine was dissolved in 1.0 ml of acetic acid, and stirred at room temperature for about 4 hours and then at 80° C. for about 3 hours. To this was added 1.0 ml of acetic acid, and cooled to room temperature. This was concentrated, and the residue formed was taken out and purified through a silica gel plate (using 91% methylene chloride/ethanol). The fraction of the intended product was extracted with methanol, and the solvent was evaporated out to obtain 11.1 mg (yield 61.5%) of the product which was white solid. The physical data of the product obtained herein were the same as those disclosed in the literature.

Provenance & Evidence