Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sertraline | HCID 68617 | — |
| Solvent | Water | HCID 962 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | — |
Reaction Steps
Alternatively, sertraline base may be combined with a solvent selected from the group consisting of ethanol, ethanol and water, ethyl acetate, and a mixture of ethyl acetate and water. The solution is heated to about 50-60° C. and water is added. The solvent is partially removed by distillation. Sertraline hydrochloride Form V is isolated by allowing the solution to cool to room temperature, followed by filtration and drying at the precipitate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06500987B1 |
|---|
| Source dataset | uspto-grants-2002_12 |
|---|
| ORD ID | ord-fa11dff120ad418b92f4ad5af5b36d17 |
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| Source note | uspto-grants-2002_12 |
|---|
