HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Sertraline Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sertraline | HCID 68617 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | 81.8% |
Reaction Steps
Sertraline base (3 g) was dissolved in absolute ethanol (15 mL) at room temperature. A saturated solution of hydrogen chloride in isopropyl alcohol was added dropwise to reach a pH of 1.3. The resulting slurry was stirred at room temperature overnight. The solid was separated by filtration and dried overnight at 50-60° C. yielding 2.75 g (81.8%) sertraline hydrochloride Form V.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500987B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-2f608838b41e461796812909cc182c27 |
| Source note | uspto-grants-2002_12 |