Hydrochloric Acid → Sertraline Hydrochloride

Participants

Reaction Steps

Sertraline base (3 g) was dissolved in 10 mL absolute ethanol at 40° C. The solution was heated to 50°-60° C. and concentrated hydrochloric acid 32% (1.2 mL) was added until pH 1.3 was reached. Water (12 mL) was added. The resulting clear solution was concentrated to half its volume and was allowed to cool naturally to room temperature. The solid was isolated by filtration, washed with water and dried overnight at 50-60° C., yielding 3.18 g (94.65%) sertraline hydrochloride Form V.

Provenance & Evidence