HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Sertraline Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sertraline | HCID 68617 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | — |
Reaction Steps
Sertraline free base was dissolved in ethanol absolute and the solution was acidified with hydrogen chloride gas to about pH 3. Precipitation occurs and the slurry was stirred at room temperature for 2 hours. The resulting solid was filtered, washed with ethanol and dried to yield sertraline hydrochloride Form V.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500987B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-e943271aaf7b4d2bbbb6874d5bf57a0c |
| Source note | uspto-grants-2002_12 |