HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl Acetate → 1,1-Dimethylethyl N-((1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl Acetate | HCID 7915 | — |
| Reactant | (2R,3S)-3-(Tert-butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane | HCID 4712659 | — |
| Product | 1,1-Dimethylethyl N-((1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl)carbamate | HCID 7146645 | — |
Reaction Steps
The thus-obtained isopropyl acetate solution was analyzed by HPLC, and it was identified that 3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane (0.57 g) was obtained in a yield of 83%. A ratio of the desired product (2S,3S) and its isomer (2R,3S) formed was (2S,3S):(2R,3S)=83.2:16.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500985B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-f2c97f95d37c4186ad1fd5c831dc69b3 |
| Source note | uspto-grants-2002_12 |