Acetyl chloride → Hydrochloric Acid

Participants

Reaction Steps

A solution of hydrogen chloride (2.3 mmol) in methanol was prepared by addition of acetyl chloride (0.165 mL, 2.3 mmol) to methanol (10 mL) and aging for 15 min. To this was added 1-(RS)-(N-(methyl)-N-(t-butoxycarbonyl)amino)-3-(SR)-((4-(N-(benzylaminocarbonyl)-N-(propyl)amino)piperidin-1-yl)methyl)-4-(SR)-phenylcyclopentane from Example 15 (135 mg, 0.23 mmol). After 16 h, the volatiles were removed in vacuo to dryness to give the title compound hydrochloride salt.

Provenance & Evidence