Phenylacetyl chloride → HCID 18345095, compound

HRID 2301794Notes

Reaction equation

C([O:5][C:6]([NH:8][C@H:9]1[CH2:13][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@@H:11]([CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([N:27]([C:31]([O:33][CH2:34][C:35]3[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=3)=[O:32])[CH2:28][CH:29]=[CH2:30])[CH2:23][CH2:22]2)[CH2:10]1)=O)(C)(C)C.[C:44]1([CH2:50]C(Cl)=O)[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1>>[CH2:50]([C:6]([NH:8][C@H:9]1[CH2:13][C@H:12]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C@@H:11]([CH2:20][N:21]2[CH2:22][CH2:23][CH:24]([N:27]([C:31]([O:33][CH2:34][C:35]3[CH:36]=[CH:37][C:38]([N+:41]([O-:43])=[O:42])=[CH:39][CH:40]=3)=[O:32])[CH2:28][CH:29]=[CH2:30])[CH2:25][CH2:26]2)[CH2:10]1)=[O:5])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 18686044HCID 18686044, compound

Product 1

HCID 18345095HCID 18345095, compound

Procedure

Using essentially the same procedure as in Example 16, Step A and B but substituting 1-(S)-((t-butoxycarbonyl)amino)-3-(S)-((4-(N-(4-nitrobenzyloxycarbonyl)-N-(allyl)amino)piperidin-1-yl)methyl)-4-(S)-phenylcyclopentane from Example 33 in Step A and phenylacetyl chloride in Step B, the title compound was prepared.

Sources & evidence

ORD record: ord-7f6927dae9ea461c8ba0010350e02bb6
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06500844B1

Reaction notes

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