HuagongsheHuagongshe Chemistry Print Report · For research reference only
N2-[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl-1,2-benzenediamine → N1-(3-Chloroindol-6-ylcarbonyl)-N2-[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl-1,2-benzenediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N2-[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl-1,2-benzenediamine | HCID 10829995 | — |
| Reactant | 3-Chloro-1H-indole-6-carboxylic acid | HCID 15543042 | — |
| Product | N1-(3-Chloroindol-6-ylcarbonyl)-N2-[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl-1,2-benzenediamine | HCID 15543030 | — |
Reaction Steps
Using the procedure described in Example 23, Part C, and purifying with preparative RPHPLC method A, N2-[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl-1,2-benzenediamine (326 mg, 1.0 mmol) and 3-chloroindole-6-carboxylic acid (195 mg, 1.0 mmol) yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500851B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-708e22c442b54b5b8769599386d6039e |
| Source note | uspto-grants-2002_12 |