HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrophenyl isocyanate → 2-[1-(4-Pyridyl)piperidin-4-ylmethylaminocarbonyl]amino-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrophenyl isocyanate | HCID 76834 | — |
| Reactant | [1-(Pyridin-4-yl)piperidin-4-yl]methanamine | HCID 10607746 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[1-(4-Pyridyl)piperidin-4-ylmethylaminocarbonyl]amino-nitrobenzene | HCID 18174469 | 64% |
Reaction Steps
A solution of 1-(4-pyridyl)piperidine-4-methylamine (1.34 g, 7.01 mmol) and 2-nitrophenyl isocyanate (1.21 g, 7.40 mmol) in methylene chloride was stirred at room temperature. Concentration in vacuo and purification by flash chromatography (silica gel, 5% methanol/1% triethylamine/94% chloroform) yielded 1.59 g (64%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500851B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-d06460e574b847c8a97afe35270ddb3b |
| Source note | uspto-grants-2002_12 |