2-Oxoglutaric Acid → L-Ornithine, 2-oxopentanedioate (1:1)

HRID 2301955Notes

Reaction equation

HRID 2301955 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4][CH2:5][NH2:6].O.[O:11]=[C:12]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[C:13]([OH:15])=[O:14]>>[O:11]=[C:12]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[C:13]([OH:15])=[O:14].[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4][CH2:5][NH2:6]

Participants

4

Reactant 3

HCID 512-Oxoglutaric AcidHCID 962WaterHCID 6262L-(-)-Ornithine

Product 1

HCID 78866L-Ornithine, 2-oxopentanedioate (1:1)

Procedure

To a basic solution of ornithine in 200 ml of water (1.1 N in water, 20 mmoles, 18.2 ml), α-keto-glutaric acid (2.92 g; 20 mmoles) is added. The solution is frozen and lyophilized one night. It is homogenized in a mortar.

Workup

  1. temperatureThe solution is frozen
  2. waitlyophilized one night

Sources & evidence

ORD record
ord-d6ac73f5b8814ad7a3b95643e8008796
Source dataset
uspto-grants-2002_08
Patent number
US06429229B1

Reaction notes

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