HCID 59812873, compound → HCID 59812953, compound

Participants

Reaction Conditions

Reaction Steps

Cyclopentyl-(4,6-dichloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol (8.1 g, 27.62 mmol) was dissolved in 100 mL dry acetone and stirred under nitrogen at 0° C. CrO3 (11.05 g, 110.497 mmol) was added in portions over three minutes. The reaction mixture was stirred for 20 minutes. The reaction was quenched by addition of 15 mL isopropanol, followed by basificaction with saturated aqueous sodium bicarbonate. The resulting solution was filtered through Celite, and the Celite was washed with acetone. The resulting solution was dried over Na2SO4, filtered, and concentrated under reduced pressure to give 3.1 g of Cyclopentyl-(4,6-dichloro-2-methylsulfanyl-pyrimidin-5-yl)-methanone. Mass Spec. M+H=292.

Provenance & Evidence