tert-butyl N-(4-bromobutyl)carbamate → [3-(4-tert-Butoxycarbonylamino-butoxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-acetic Acid Ethyl Ester
Reaction equation
[C:1]([O:5][C:6](=[O:13])[NH:7][CH2:8][CH2:9][CH2:10][CH2:11]Br)([CH3:4])([CH3:3])[CH3:2].[CH2:14]([O:16][C:17](=[O:31])[CH2:18][CH:19]1[CH2:25][CH2:24][CH2:23][C:22]2[CH:26]=[CH:27][C:28]([OH:30])=[CH:29][C:21]=2[CH2:20]1)[CH3:15]>>[CH2:14]([O:16][C:17](=[O:31])[CH2:18][CH:19]1[CH2:25][CH2:24][CH2:23][C:22]2[CH:26]=[CH:27][C:28]([O:30][CH2:11][CH2:10][CH2:9][CH2:8][NH:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:13])=[CH:29][C:21]=2[CH2:20]1)[CH3:15]Participants
3
Procedure
The title compound is prepared according to the procedure of Example 19 except that (4-bromo-butyl)-carbamic acid tert-butyl ester is used in place of (3-bromo-propyl)-carbamic acid tert-butyl ester and (3-hydroxy-6,7,8,9-tetrahydro-5H-benzo-cyclohepten-6-yl)-acetic acid ethyl ester is used in place of (7-hydroxy-1,2,3,4-tetrahydro-napthalen-2-yl)-acetic acid ethyl ester.
Sources & evidence
- ORD record
- ord-de38a83a39ef4fdd8d3b3460eb91d695
- Source dataset
- uspto-grants-2002_08
- Patent number
- US06429214B1
Reaction notes
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