反应详情

温度

250 °C

A suspension of (1-ethyl-7-methoxy-2-oxo-1,2-dihydro-quinolin-3-yl)-acetic acid methyl ester (4.0 g, 14.5 mmol) in 1:1 48% aqueous HBr—HOAc (30 mL) was heated at reflux for 48 h. The resulting solution was cooled to 250° C. and the resulting crystalline solid was stored at 0-50° C. for 2 h, then vacuum filtered, washed with water and air-dried to give the title compound (3.2 g, 89% yield) as tan needles.

1. temperaturewas heated
2. temperatureat reflux for 48 h
3. filtrationvacuum filtered
4. washwashed with water
5. customair-dried