[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester → [1-Ethyl-7-(2-aminoethoxy)-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester

HRID 2301985Notes

Reaction equation

HRID 2301985 reaction equation
COC(=O)CC1CC2C(=CC(OCCNC(OC(C)(C)C)=O)=CC=2)NC1=O.[CH3:28][O:29][C:30](=[O:56])[CH2:31][C:32]1[C:33](=[O:55])[N:34]([CH2:53][CH3:54])[C:35]2[C:40]([CH:41]=1)=[CH:39][CH:38]=[C:37]([O:42][CH2:43][CH2:44][NH:45]C(OC(C)(C)C)=O)[CH:36]=2>>[CH3:28][O:29][C:30](=[O:56])[CH2:31][C:32]1[C:33](=[O:55])[N:34]([CH2:53][CH3:54])[C:35]2[C:40]([CH:41]=1)=[CH:39][CH:38]=[C:37]([O:42][CH2:43][CH2:44][NH2:45])[CH:36]=2

Participants

3

Reactant 2

HCID 18462590[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl esterHCID 69978155[7-(2-Tert-butoxycarbonylaminoethoxy)-1-ethyl-2-oxo-1,2-dihydro-quinolin-3-yl]acetic acid methyl ester

Product 1

HCID 69978617[1-Ethyl-7-(2-aminoethoxy)-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester

Procedure

The title compound is prepared according to the procedure of Example 78 except that [7-(2-tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester is replaced with [7-(2-tert-butoxycarbonylaminoethoxy)-1-ethyl-2-oxo-1,2-dihydro-quinolin-3-yl]acetic acid methyl ester.

Sources & evidence

ORD record
ord-e63fa1002aaa4937aaa248ec6b27f521
Source dataset
uspto-grants-2002_08
Patent number
US06429214B1

Reaction notes

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