[7-(3-tert-Butoxycarbonylaminopropoxy)-1-ethyl-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester → [1-Ethyl-7-(3-aminopropoxy)-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester

HRID 2301986Notes

Reaction equation

HRID 2301986 reaction equation
COC(=O)CC1CC2C(=CC(OCC(N=C=O)OC(C)(C)C)=CC=2)NC1=O.[CH3:28][O:29][C:30](=[O:57])[CH2:31][C:32]1[C:33](=[O:56])[N:34]([CH2:54][CH3:55])[C:35]2[C:40]([CH:41]=1)=[CH:39][CH:38]=[C:37]([O:42][CH2:43][CH2:44][CH2:45][NH:46]C(OC(C)(C)C)=O)[CH:36]=2>>[CH3:28][O:29][C:30](=[O:57])[CH2:31][C:32]1[C:33](=[O:56])[N:34]([CH2:54][CH3:55])[C:35]2[C:40]([CH:41]=1)=[CH:39][CH:38]=[C:37]([O:42][CH2:43][CH2:44][CH2:45][NH2:46])[CH:36]=2

Participants

3

Reactant 2

HCID 69978591[7-(3-tert-Butoxycarbonylaminopropoxy)-1-ethyl-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl EsterHCID 86588378[7-(2-Tert-butoxy-carbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]acetic acid methyl ester

Product 1

HCID 69978044[1-Ethyl-7-(3-aminopropoxy)-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester

Procedure

The title compound is prepared according to the procedure of Example 78 except that [7-(2-tert-butoxy-carbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]acetic acid methyl ester is replaced with [7-(3-tert-butoxycarbonylaminopropoxy)-1-ethyl-2-oxo-1,2-dihydro-quinolin-3-yl]acetic acid methyl ester.

Sources & evidence

ORD record
ord-b2f3a01223a64763be93dca292400e35
Source dataset
uspto-grants-2002_08
Patent number
US06429214B1

Reaction notes

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