[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester → [1-Ethyl-7-(4-aminobutoxy)-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester

HRID 2301987Notes

Reaction equation

HRID 2301987 reaction equation
COC(=O)CC1CC2C(=CC(OCCNC(OC(C)(C)C)=O)=CC=2)NC1=O.[CH3:28][O:29][C:30](=[O:58])[CH2:31][C:32]1[C:33](=[O:57])[N:34]([CH2:55][CH3:56])[C:35]2[C:40]([CH:41]=1)=[CH:39][CH:38]=[C:37]([O:42][CH2:43][CH2:44][CH2:45][CH2:46][NH:47]C(OC(C)(C)C)=O)[CH:36]=2>>[CH3:28][O:29][C:30](=[O:58])[CH2:31][C:32]1[C:33](=[O:57])[N:34]([CH2:55][CH3:56])[C:35]2[C:40]([CH:41]=1)=[CH:39][CH:38]=[C:37]([O:42][CH2:43][CH2:44][CH2:45][CH2:46][NH2:47])[CH:36]=2

Participants

3

Reactant 2

HCID 18462590[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl esterHCID 69978658[7-(4-tert-Butoxycarbonylaminobutoxy)-1-ethyl-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester

Product 1

HCID 69978662[1-Ethyl-7-(4-aminobutoxy)-2-oxo-1,2-dihydro-quinolin-3-yl]acetic Acid Methyl Ester

Procedure

The title compound is prepared according to the procedure of Example 78 except that [7-(2-tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester is replaced with [7-(4-tert-butoxycarbonylaminobutoxy)-1-ethyl-2-oxo-1,2-dihydro-quinolin-3-yl]acetic acid methyl ester.

Sources & evidence

ORD record
ord-b122d0e1e90d4b4ca13715cc12578f19
Source dataset
uspto-grants-2002_08
Patent number
US06429214B1

Reaction notes

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