[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester → [1-Benzyl-7-(2-aminoethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic Acid Methyl Ester

HRID 2301999Notes

Reaction equation

HRID 2301999 reaction equation
COC(=O)CC1CC2C(=CC(OCCNC(OC(C)(C)C)=O)=CC=2)NC1=O.[CH3:28][O:29][C:30](=[O:61])[CH2:31][CH:32]1[CH2:41][C:40]2[C:35](=[CH:36][C:37]([O:42][CH2:43][CH2:44][NH:45]C(OC(C)(C)C)=O)=[CH:38][CH:39]=2)[N:34]([CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=2)[C:33]1=[O:60]>>[CH3:28][O:29][C:30](=[O:61])[CH2:31][CH:32]1[CH2:41][C:40]2[C:35](=[CH:36][C:37]([O:42][CH2:43][CH2:44][NH2:45])=[CH:38][CH:39]=2)[N:34]([CH2:53][C:54]2[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=2)[C:33]1=[O:60]

Participants

3

Reactant 2

HCID 18462590[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl esterHCID 69978640[7-(2-Tert-butoxycarbonylaminoethoxy)-1-benzyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester

Product 1

HCID 69979600[1-Benzyl-7-(2-aminoethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic Acid Methyl Ester

Procedure

The title compound is prepared according to the procedure of Example 78 except that [7-(2-tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-acetic acid methyl ester is replaced with [7-(2-tert-butoxycarbonylaminoethoxy)-1-benzyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester.

Sources & evidence

ORD record
ord-bdf698602cc546a1b9eba0f0f6f5049a
Source dataset
uspto-grants-2002_08
Patent number
US06429214B1

Reaction notes

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