[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester → [1-Benzyl-7-(4-aminobutoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic Acid Methyl Ester

HRID 2302000Notes

Reaction equation

HRID 2302000 reaction equation
COC(=O)CC1CC2C(=CC(OCCNC(OC(C)(C)C)=O)=CC=2)NC1=O.[CH3:28][O:29][C:30](=[O:63])[CH2:31][CH:32]1[CH2:41][C:40]2[C:35](=[CH:36][C:37]([O:42][CH2:43][CH2:44][CH2:45][CH2:46][NH:47]C(OC(C)(C)C)=O)=[CH:38][CH:39]=2)[N:34]([CH2:55][C:56]2[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=2)[C:33]1=[O:62]>>[CH3:28][O:29][C:30](=[O:63])[CH2:31][CH:32]1[CH2:41][C:40]2[C:35](=[CH:36][C:37]([O:42][CH2:43][CH2:44][CH2:45][CH2:46][NH2:47])=[CH:38][CH:39]=2)[N:34]([CH2:55][C:56]2[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=2)[C:33]1=[O:62]

Participants

3

Reactant 2

HCID 18462590[7-(2-Tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl esterHCID 69979392[7-(4-tert-Butoxycarbonylaminobutoxy)-1-benzyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic Acid Methyl Ester

Product 1

HCID 69979749[1-Benzyl-7-(4-aminobutoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic Acid Methyl Ester

Procedure

The title compound is prepared according to the procedure of Example 78 except that [7-(2-tert-butoxycarbonylamino-ethoxy)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-acetic acid methyl ester is replaced with [7-(4-tert-butoxycarbonylaminobutoxy)-1-benzyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]acetic acid methyl ester.

Sources & evidence

ORD record
ord-dd0058e8cdc14cdc82e653b597f04641
Source dataset
uspto-grants-2002_08
Patent number
US06429214B1

Reaction notes

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