HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2302006Generated: October 30, 2026
Hydrochloric Acid → 3-Methoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-carboxylic Acid
https://huagongshe.com/reaction/2302006
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Methoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinoline-7-carboxylic acid tert-butyl ester | HCID 69979859 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Methoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-carboxylic Acid | HCID 18462657 | 97% |
Reaction Steps
A suspension of 3-methoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinoline-7-carboxylic acid tert-butyl ester (3.5 g, 13.2 mmol) in dioxane (40 mL) was treated with 10 mL of 4N hydrochloric acid in dioxane and heated to 40-50° C. Evaporation of the volatiles in vacuo gave the title compound (3.35 g, 97%). NMR (dmso-d6, 200 MHz) : δ2.7-3.4 (m, 5H, CH2CHCH2), 3.6 (s, 3H, CH3), 7.2-7.5 (m, 3H, ArH), 10.3 (s, 1 H, NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06429214B1 |
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| Source dataset | uspto-grants-2002_08 |
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| ORD ID | ord-5665534271d242be9b434914317578fb |
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| Source note | uspto-grants-2002_08 |
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