HCID 12696803, compound → Clortermine

HRID 2302049Notes

Reaction equation

HRID 2302049 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([CH3:14])([N+:11]([O-])=O)[CH3:10]>[Ni].C(O)C>[CH3:14][C:9]([NH2:11])([CH3:10])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1]

Participants

4

Reactant 1

HCID 12696803HCID 12696803, compound

Product 1

HCID 25223Clortermine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of Raney nickel (50% by weight in water; 2.3 g) and 1-(2-chlorophenyl)-2-methyl-2-nitropropane (2.35 g, 11 mmol) in ethanol (35 mL) was shaken under hydrogen gas (60 psig) for 3.5 h. The reaction mixture was then filtered, and the filtrate was rotary evaporated. This provided 2.3 g (110%) of α,α-dimethyl-2-chlorophenethylamine.

Workup

  1. filtrationThe reaction mixture was then filtered

Sources & evidence

ORD record
ord-9f56e6d4d55f468da56161d30a382847
Source dataset
uspto-grants-2002_08
Patent number
US06429207B1

Reaction notes

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