Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Amino-1-butanol, (-)- | HCID 2723856 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 22957230 | HCID 22957230 | 70.7% |
Reaction Steps
Four grams of 2-(R)-aminobutanol and 7.2 grams of NaOH are suspended in toluene in a round bottom flask at ambient temperature. Benzenesulfonyl chloride (16.7 g) is added with agitation in one portion. The resulting white suspension is heated at 62° C. for 6 hours. Water (90 mL) is added and the layers are separated. The organic layer is washed with 70 ml of water, dried over magnesium sulfate and concentrated to provide 1-benzenesulfonyl-2(R)-ethylaziridine (6.7 g) as a colorless oil which is purified by flash chromatography over silica gel. MS: m/z (E1, 70EV) 212 (20%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06429315B1 |
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| Source dataset | uspto-grants-2002_08 |
|---|
| ORD ID | ord-94b4e1c660a84324bd8aafd5c2c0030b |
|---|
| Source note | uspto-grants-2002_08 |
|---|
