HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2302086Generated: November 1, 2026
Water → (R)-N-[1-[(3-chlorothien-2-yl)methyl]propyl]-4-methylbenzenesulfonamide
https://huagongshe.com/reaction/2302086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (R)-N-[1-[(3-chlorothien-2-yl)methyl]propyl]-4-methylbenzenesulfonamide lithium salt | HCID 69848256 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-N-[1-[(3-chlorothien-2-yl)methyl]propyl]-4-methylbenzenesulfonamide | HCID 11002430 | 95% |
Reaction Steps
A mixture of 50.0 g (0.143 mol) of (R)-N-[1-[(3-chlorothien-2-yl )methyl]propyl]-4-methylbenzenesulfonamide lithium salt, prepared as described in PCT/US97/15729, in 50 g methanol is heated with stirring at 65° C. until dissolution of the solids is completed. The solution is cooled to 60° C. and 85 g water is added to the mixture dropwise. The mixture is stirred for 1.5 hours and then cooled to 20° C. The solids are isolated by filtration. Drying under vacuum with nitrogen bleed affords 46.6 g (95%) of the free base (R)-N-[1-[(3-chlorothien-2-yl)methyl]propyl]-4-methylbenzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06429315B1 |
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| Source dataset | uspto-grants-2002_08 |
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| ORD ID | ord-558184f185874d8ca70ae827d7e11278 |
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| Source note | uspto-grants-2002_08 |
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