Hydrochloric Acid → HCID 15279120, compound

Participants

Reaction Steps

The obtained 1-(1-cyano-1-trimethylsilyloxyethyl)adamantane was added to 45 ml of tetrahydrofuran and 17 ml of 2N-hydrochloric acid, and the resultant mixture was refluxed with stirring for 3 hours. After cooling the reaction mixture and adding an aqueous solution (water: 170 ml) of potassium hydrogencarbonate (11 g) thereto, the resultant mixture was extracted with ether, and the obtained organic layer was concentrated to give 24.1 g of 1-(1-cyano-1-hydroxyethyl)adamantane (white solid substance).

Provenance & Evidence