HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-((4-Chlorophenoxy)methyl)oxirane → N-[2-Hydroxy-3-(4-chlorophenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-((4-Chlorophenoxy)methyl)oxirane | HCID 91515 | — |
| Reactant | 2-(4-Methoxyphenyl)-1,1-dimethylethylamine | HCID 91892 | — |
| Product | N-[2-Hydroxy-3-(4-chlorophenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine Hydrochloride | HCID 18459608 | 135.9% |
Reaction Steps
Using the method of Example 6, supra, 4-chlorophenyl glycidyl ether (185 mg, 1 mmol) and 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine (269 mg, 1.5 mmol) were used to prepare 272 mg of the title compound as a white solid: GC/EI-MS, m/z (rel. int.) 348 (M−15, 1), 244 (35), 243 (15), 242 (100), 163 (9), 121 (24), 114 (7), 71 (24), 70 (26), 58 (15), 42 (7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432656B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-93d5bafc1094422e9998dd62756819c9 |
| Source note | uspto-grants-2002_08 |