Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → n-(2-Hydroxy-3phenoxypropyl)-1,1-dimethyl-2-phenylethylamine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | N-[2-Hydroxy-3-(4-methoxyphenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine Hydrochloride | HCID 22640899 | — |
| 반응물 | N-(2-Hydroxy-3-isopropoxypropyl)-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine | HCID 22640903 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | n-(2-Hydroxy-3phenoxypropyl)-1,1-dimethyl-2-phenylethylamine hydrochloride | HCID 22640946 | — |
반응 단계
Using the method of Example 5, supra, 1,2-epoxy-3-phenoxypropane (600 mg, 4 mmol) and 1,1-dimethyl-2-phenylethylamine (596 mg, 4 mmol) yielded the title compound: GC/EI-MS, m/z (rel. int.) 284 (M+1, 1), 208 (100), 162 (1), 133 (7), 91 (27), 77 (15), 70 (22). The free base in diethyl ether was treated with excess 1M HCl (diethyl ether). The resulting solid was recrystallized from hot acetonitrile to afford 596 mg of the hydrochloride product as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06432656B1 |
| 출처 데이터셋 | uspto-grants-2002_08 |
| ORD ID | ord-7f86791ab91341ceb7ce1c788110b7c0 |
| 출처 메모 | uspto-grants-2002_08 |