Hydrochloric Acid → 163558-44-9

Participants

Reaction Steps

10% palladium on charcoal (1.2 g) was added to a solution of Cbz-D-Tyr(tBu)-OMe (10.2 g) in methanol (100 ml) and 4N hydrogen chloride (5 ml). The mixture was hydrogenated at atmospheric pressure at room temperature for 2 hours. The palladium catalyst was removed by filtration. The filtrate was concentrated to a small volume followed by cystallisation from diethyl ether. Yield: 5.87 g. TLC: Rf=0.10, heptane/ethyl acetate 1/1.

Provenance & Evidence