HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 195532-64-0 | HCID 18417533 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Cyano-2,4,5-trifluoro-benzoyl chloride | HCID 18618761 | 97% |
Reaction Steps
111 g of 3-cyano-2,4,5-trifluoro-benzoic acid and 84 g of oxalyl chloride are stirred at room temperature for 5 hours in 930 ml of dry methylene chloride with addition of a few drops of dimethylformamide. The methylene chloride is then stripped off and the residue is distilled in vacuo. 117.6 g of 3-cyano-2,4,5-trifluoro-benzoyl chloride are obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432948B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-5be8186983b246bc851e4f962a31ac17 |
| Source note | uspto-grants-2002_08 |