反应详情

温度

30 °C

30 g of glacial acetic acid are added dropwise at 20° C. to the reaction product from stage e. A solution of 15.75 g of cyclopropylamine in 30 ml of toluene is then added dropwise. The mixture is stirred at 30° C. for 1 hour. 200 ml of water are then added, the mixture is stirred for 15 minutes, and the organic phase is separated off and again extracted by shaking with 100 ml of water. The organic phase is then dried over sodium sulphate and concentrated in vacuo. The crude product thus obtained is employed in the next stage without further working up.

1. stirringthe mixture is stirred for 15 minutes
2. customthe organic phase is separated off
3. extractionagain extracted
4. stirringby shaking with 100 ml of water
5. dry with materialThe organic phase is then dried over sodium sulphate
6. concentrationconcentrated in vacuo